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The Relationship Between XRCC1 and XRCC6 Genes Polymorphisms and Renal Cell Carcinoma


1 Genetic Sciences Student and Researcher, Qom and Surgical Technologist, Kashan University of Medical Sciences, Kashan, IR Iran
2 General Surgery Specialist, Medical School, Kashan University of Medical Sciences, Kashan, IR Iran
3 Instructor of Education Office, Isfahan, IR Iran
*Corresponding author: Sayed Alireza Mirsane, Genetic Sciences Student and Researcher, Qom and Surgical Technologist, Kashan University of Medical Sciences, Kashan, IR Iran, E-mail: alireza.seyed70@gmail.com.
Gene, Cell and Tissue. 4(1): e42442 , DOI: 10.17795/gct-42442
Article Type: Letter; Received: Sep 21, 2016; Revised: Nov 19, 2016; Accepted: Nov 23, 2016; epub: Nov 27, 2016; collection: Jan 2017

Keywords: XRCC1; XRCC6; Polymorphism; Renal Cell Carcinoma


Dear Editor,


Polymorphisms of genes can cause a decrease in DNA repair capacity and disease susceptibility, as well (1, 2). The XRCC genes play a momentous role in comprehension processes of DNA repair in mammals, especially in double-strand break (DSB) repair (3). Therefore, normal activity of XRCC genes is a major factor for cancer prevention. On the other hand, approximately, 84400 new patients of renal cell carcinoma (RCC) are recognized by the Union of Europe. In addition, 34700 kidney cancer-related deaths happened in 2012 (4). The present study aimed to review the correlation between some XRCC1 and XRCC6 genes polymorphism and RCC. In a case control study assessing the relationship between XRCC6 C-1310G (rs2267437) polymorphism and RCC susceptibility, the results indicated that the polymorphism of XRCC6 C-1310G is involved in the etiology of RCC and it can be as a marker in the susceptibility to RCC (5). Furthermore, in a hospital-based case–control study, the association between XRCC6 T-991C (rs5751129) polymorphisms and RCC risk in a Taiwanese population was evaluated. Results of this investigation showed that the XRCC6 T-991C polymorphism is associated with RCC. This polymorphism can lead to the different mRNA expression levels, which can affect expression of the XRCC6 protein and capacity of DSB repair (6). Moreover, Wang et al. in their paper stated that the XRCC6 A-31G polymorphism (rs132770) is associated with the RCC risk and they also suggested that the XRCC6 A-31G polymorphism is an important subject in the RCC etiology (7). On the other hand, regarding the correlation between XRCC1 gene polymorphism and RCC, Hirata et al. (8) declared that XRCC1 399Gln polymorphism can be a risk factor for RCC and their results suggested that the XRCC1 399Gln allele may be linked to RCC susceptibility. In another study, Akhmadishina et al. (9) detected an association between allele A of the c.839G > A locus of the XRCC1 gene and the RCC occurrence and also they declared that polymorphism of c.839G > A in the XRCC1 gene can be contributed in RCC progress at the advanced and early stages of this disease. According to the results, we can understand that polymorphisms of XRCC1 and XRCC6 may greatly be associated with RCC, so that, XRCC6 may be a marker in genetic susceptibility to RCC and a significant subject in its etiology. In addition, XRCC1 can be linked to RCC progress at the advanced and early stages of it or susceptibility to RCC. Finally, it is advised to conduct more studies in order to obtain the comprehensive results regarding RCC and the genes.

References


  • 1. Mirsane SA, Shafagh S. The Relationship Between XRCC1 Arg399Gln Polymorphism, Alcohol Consumption and Colorectal Cancer: One of the Alcohol Forbidding Reasons in Islam. Gene, Cell and Tissue. 2016;3(3):40607.
  • 2. Mirsane SA, Shafagh S, Oraei N. The Relationship Between Polymorphisms of FTO Gene and Type 2 Diabetes Mellitus. Gene, Cell and Tissue. 2016;inpress(inpress)
  • 3. Thacker J, Zdzienicka MZ. The mammalian XRCC genes: their roles in DNA repair and genetic stability. DNA Repair (Amst). 2003;2(6):655-72. [DOI] [PubMed]
  • 4. Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, Rosso S, Coebergh JW, Comber H, et al. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur J Cancer. 2013;49(6):1374-403. [DOI] [PubMed]
  • 5. Wang W, Pan X, Huo X, Yan F, Wang M, Wang D. A functional polymorphism C‐1310G in the promoter region of Ku70/XRCC6 is associated with risk of renal cell carcinoma. Molecul Carcinogene. 2012;51(1) [DOI]
  • 6. Chang WS, Ke HL, Tsai CW, Lien CS, Liao WL, Lin HH, et al. The role of XRCC6 T-991C functional polymorphism in renal cell carcinoma. Anticancer Res. 2012;32(9):3855-60. [PubMed]
  • 7. Wang W, Gao Y, Yan F, Wang M, Hu F, Wang D, et al. Association of Ku70 A-31G polymorphism and risk of renal cell carcinoma in a Chinese population. DNA Cell Biol. 2012;31(7):1314-20. [DOI] [PubMed]
  • 8. Hirata H, Hinoda Y, Matsuyama H, Tanaka Y, Okayama N, Suehiro Y, et al. Polymorphisms of DNA repair genes are associated with renal cell carcinoma. Biochem Biophys Res Commun. 2006;342(4):1058-62. [DOI] [PubMed]
  • 9. Akhmadishina LZ, Giliazova IR, Kutlyeva LR, Korytina GF, Kochetova OV, Urmantsev MF, et al. [DNA repair XRCC1, XPD genes polymorphism as associated with the development of bladder cancer and renal cell carcinoma]. Genetika. 2014;50(4):481-90. [DOI] [PubMed]