Gene, Cell and Tissue

Published by: Kowsar

Comparison of Proinflammatory Gene Expression in Lesions Caused by either Burn Injuries or Cutaneous Leishmaniasis

Soheila Akhzari 1 , Hossein Rezvan 2 , * , Seyed Masoud Zolhavarieh 3 and Mohammad Moafi 4
Authors Information
1 MSc Student of Parasitology, Department of Pathobiology, Faculty of Veterinary Science, Bu-Ali Sina University, Hamedan, IR Iran
2 PhD in Immunoparasitology, Department of Pathobiology, Faculty of Veterinary Science, Bu-Ali Sina University, Hamedan, IR Iran
3 DVM, DVSc, Department of Clinical Sciences, Faculty of Veterinary Science, Bu-Ali Sina University, Hamedan, IR Iran
4 PhD Student of Immunology, Department of Pathobiology, Faculty of Veterinary Science, Bu-Ali Sina University, Hamedan, IR Iran
Article information
  • Gene, Cell and Tissue: January 2017, 4 (1); e13324
  • Published Online: December 26, 2016
  • Article Type: Research Article
  • Received: October 10, 2016
  • Revised: December 19, 2016
  • Accepted: December 20, 2016
  • DOI: 10.17795/gct-42887

To Cite: Akhzari S, Rezvan H, Zolhavarieh S M, Moafi M. Comparison of Proinflammatory Gene Expression in Lesions Caused by either Burn Injuries or Cutaneous Leishmaniasis, Gene Cell Tissue. 2017 ; 4(1):e13324. doi: 10.17795/gct-42887.

Copyright © 2016, Zahedan University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Rezvan H, Moafi M. An overview on Leishmania vaccines: A narrative review article. Vet Res Forum. 2015; 6(1): 1-7[PubMed]
  • 2. Eiras DP, Kirkman LA, Murray HW. Cutaneous Leishmaniasis: Current Treatment Practices in the USA for Returning Travelers. Curr Treat Options Infect Dis. 2015; 7(1): 52-62[DOI][PubMed]
  • 3. Carvalho AM, Cristal JR, Muniz AC, Carvalho LP, Gomes R, Miranda JC, et al. Interleukin 10-Dominant Immune Response and Increased Risk of Cutaneous Leishmaniasis After Natural Exposure to Lutzomyia intermedia Sand Flies. J Infect Dis. 2015; 212(1): 157-65[DOI]
  • 4. Gois L, Badaro R, Schooley R, Grassi MF. Immune response to Leishmania antigens in an AIDS patient with mucocutaneous leishmaniasis as a manifestation of immune reconstitution inflammatory syndrome (IRIS): a case report. BMC Infect Dis. 2015; 15: 38[DOI][PubMed]
  • 5. Akbari M, Honma K, Kimura D, Miyakoda M, Kimura K, Matsuyama T, et al. IRF4 in dendritic cells inhibits IL-12 production and controls Th1 immune responses against Leishmania major. J Immunol. 2014; 192(5): 2271-9[DOI][PubMed]
  • 6. Martinez-Lopez M, Iborra S, Conde-Garrosa R, Sancho D. Batf3-dependent CD103+ dendritic cells are major producers of IL-12 that drive local Th1 immunity against Leishmania major infection in mice. Eur J Immunol. 2015; 45(1): 119-29[DOI][PubMed]
  • 7. Oghumu S, Stock JC, Varikuti S, Dong R, Terrazas C, Edwards JA, et al. Transgenic expression of CXCR3 on T cells enhances susceptibility to cutaneous Leishmania major infection by inhibiting monocyte maturation and promoting a Th2 response. Infect Immun. 2015; 83(1): 67-76[DOI][PubMed]
  • 8. Ashcroft GS, Jeong MJ, Ashworth JJ, Hardman M, Jin W, Moutsopoulos N, et al. Tumor necrosis factor-alpha (TNF-alpha) is a therapeutic target for impaired cutaneous wound healing. Wound Repair Regen. 2012; 20(1): 38-49[DOI][PubMed]
  • 9. Yan C, Gao N, Sun H, Yin J, Lee P, Zhou L, et al. Targeting Imbalance between IL-1beta and IL-1 Receptor Antagonist Ameliorates Delayed Epithelium Wound Healing in Diabetic Mouse Corneas. Am J Pathol. 2016; 186(6): 1466-80[DOI][PubMed]
  • 10. Ferrante CJ, Leibovich SJ. Regulation of Macrophage Polarization and Wound Healing. Adv Wound Care (New Rochelle). 2012; 1(1): 10-6[DOI][PubMed]
  • 11. Kurey I, Kobets T, Havelkova H, Slapnickova M, Quan L, Trtkova K, et al. Distinct genetic control of parasite elimination, dissemination, and disease after Leishmania major infection. Immunogenetics. 2009; 61(9): 619-33[DOI][PubMed]
  • 12. Oryan A. Plant-derived compounds in treatment of leishmaniasis. Iran J Vet Res. 2015; 16(1): 1-19[PubMed]
  • 13. Salman KD, Salman SQ, Abdulraheem GA. Immunogenic Potential of Cytosolic Proteins Against Visceral Leishmaniasis in BALB/C Mice and the Role of Chitosan as Adjuvant. Int J Adv Technol Innov Res. 2015; 7(4): 540-5
  • 14. Inatsu A, Kogiso M, Jeschke MG, Asai A, Kobayashi M, Herndon DN, et al. Lack of Th17 cell generation in patients with severe burn injuries. J Immunol. 2011; 187(5): 2155-61[DOI][PubMed]
  • 15. Sacks D, Noben-Trauth N. The immunology of susceptibility and resistance to Leishmania major in mice. Nat Rev Immunol. 2002; 2(11): 845-58[DOI][PubMed]
  • 16. Oliveira F, Bafica A, Rosato AB, Favali CB, Costa JM, Cafe V, et al. Lesion size correlates with Leishmania antigen-stimulated TNF-levels in human cutaneous leishmaniasis. Am J Trop Med Hyg. 2011; 85(1): 70-3[DOI][PubMed]
  • 17. Bousquet E, Mura F, Villain M, Riviere S, Konate A, Schneider C. [Infectious complications in patients treated with anti-TNF-alpha: two cases of leishmaniasis]. J Fr Ophtalmol. 2012; 35(9): 695-9[DOI][PubMed]
  • 18. Huber NL, Bailey SR, Schuster R, Ogle CK, Lentsch AB, Pritts TA. Prior thermal injury accelerates endotoxin-induced inflammatory cytokine production and intestinal nuclear factor-kappaB activation in mice. J Burn Care Res. 2012; 33(2): 279-85[DOI][PubMed]
  • 19. Das S, Banerjee S, Majumder S, Chowdhury BP, Goswami A, Halder K, et al. Immune subversion by Mycobacterium tuberculosis through CCR5 mediated signaling: involvement of IL-10. PLoS One. 2014; 9(4)[DOI][PubMed]
  • 20. Yurchenko E, Tritt M, Hay V, Shevach EM, Belkaid Y, Piccirillo CA. CCR5-dependent homing of naturally occurring CD4+ regulatory T cells to sites of Leishmania major infection favors pathogen persistence. J Exp Med. 2006; 203(11): 2451-60[DOI][PubMed]
  • 21. Spees AM, Kingsbury DD, Wangdi T, Xavier MN, Tsolis RM, Baumler AJ. Neutrophils are a source of gamma interferon during acute Salmonella enterica serovar Typhimurium colitis. Infect Immun. 2014; 82(4): 1692-7[DOI][PubMed]
  • 22. Sturge CR, Benson A, Raetz M, Wilhelm CL, Mirpuri J, Vitetta ES, et al. TLR-independent neutrophil-derived IFN-gamma is important for host resistance to intracellular pathogens. Proc Natl Acad Sci U S A. 2013; 110(26): 10711-6[DOI][PubMed]
  • 23. Rodrigues DR, Fernandes RK, Balderramas Hde A, Penitenti M, Bachiega TF, Calvi SA, et al. Interferon-gamma production by human neutrophils upon stimulation by IL-12, IL-15 and IL-18 and challenge with Paracoccidioides brasiliensis. Cytokine. 2014; 69(1): 102-9[DOI][PubMed]
  • 24. Cai S, Batra S, Langohr I, Iwakura Y, Jeyaseelan S. IFN-gamma induction by neutrophil-derived IL-17A homodimer augments pulmonary antibacterial defense. Mucosal Immunol. 2016; 9(3): 718-29[DOI][PubMed]
  • 25. Haverkamp MH, van de Vosse E, van Dissel JT. Nontuberculous mycobacterial infections in children with inborn errors of the immune system. J Infect. 2014; 68 Suppl 1-50[DOI][PubMed]
  • 26. Balderramas HA, Penitenti M, Rodrigues DR, Bachiega TF, Fernandes RK, Ikoma MR, et al. Human neutrophils produce IL-12, IL-10, PGE2 and LTB4 in response to Paracoccidioides brasiliensis. Involvement of TLR2, mannose receptor and dectin-1. Cytokine. 2014; 67(1): 36-43[DOI][PubMed]
  • 27. Bliss SK, Butcher BA, Denkers EY. Rapid recruitment of neutrophils containing prestored IL-12 during microbial infection. J Immunol. 2000; 165(8): 4515-21[PubMed]
  • 28. Ajdary S, Alimohammadian MH, Eslami MB, Kemp K, Kharazmi A. Comparison of the immune profile of nonhealing cutaneous Leishmaniasis patients with those with active lesions and those who have recovered from infection. Infect Immun. 2000; 68(4): 1760-4[PubMed]
  • 29. Habibi GR, Khamesipour A, McMaster WR, Mahboudi F. Cytokine gene expression in healing and non-healing cases of cutaneous leishmaniasis in response to in vitro stimulation with recombinant gp63 using semi-quantitative RT-PCR. Scand J Immunol. 2001; 54(4): 414-20[PubMed]
  • 30. Mendelian susceptibility to mycobacterial disease: genetic, immunological, and clinical features of inborn errors of IFN-γ immunity. Seminars in immunology. : 454-70
  • 31. Carlsen ED, Liang Y, Shelite TR, Walker DH, Melby PC, Soong L. Permissive and protective roles for neutrophils in leishmaniasis. Clin Exp Immunol. 2015; 182(2): 109-18[DOI][PubMed]
  • 32. Fernandez-Figueroa EA, Rangel-Escareno C, Espinosa-Mateos V, Carrillo-Sanchez K, Salaiza-Suazo N, Carrada-Figueroa G, et al. Disease severity in patients infected with Leishmania mexicana relates to IL-1beta. PLoS Negl Trop Dis. 2012; 6(5)[DOI][PubMed]
  • 33. Moreno E, Schwartz J, Larrea E, Conde I, Font M, Sanmartin C, et al. Assessment of beta-lapachone loaded in lecithin-chitosan nanoparticles for the topical treatment of cutaneous leishmaniasis in L. major infected BALB/c mice. Nanomedicine. 2015; 11(8): 2003-12[DOI][PubMed]
  • 34. Marques CS, Passero LF, Vale-Gato I, Rodrigues A, Rodrigues OR, Martins C, et al. New insights into neutrophil and Leishmania infantum in vitro immune interactions. Comp Immunol Microbiol Infect Dis. 2015; 40: 19-29[DOI][PubMed]
  • 35. Filardy AA, Costa-da-Silva AC, Koeller CM, Guimaraes-Pinto K, Ribeiro-Gomes FL, Lopes MF, et al. Infection with Leishmania major induces a cellular stress response in macrophages. PLoS One. 2014; 9(1)[DOI][PubMed]
  • 36. Blazek K, Eames HL, Weiss M, Byrne AJ, Perocheau D, Pease JE, et al. IFN-lambda resolves inflammation via suppression of neutrophil infiltration and IL-1beta production. J Exp Med. 2015; 212(6): 845-53[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments