Gene, Cell and Tissue

Published by: Kowsar

Digoxin Effectively Inhibited Cell Growth and Induced Senescence in Cervical Cancer Cell Line

Atefeh Tahervand 1 , Behnaz Parnian 1 , Mehryar Habibi Roudkenar 2 and Amaneh Mohammadi Roushandeh 3 , *
Authors Information
1 Biology Department, Basic Sciences faculty, Islamic Azad University of Hamadan, Hamadan, Iran
2 Medical Biotechnology Research Center, Faculty of Paramedicine, Guilan University of Medical Sciences, Rasht, Iran
3 Anatomical Sciences Department, Medicine Faculty, Hamadan University of Medical Sciences, Hamadan, Iran
Article information
  • Gene, Cell and Tissue: April 2017, 4 (2); e14216
  • Published Online: April 30, 2017
  • Article Type: Research Article
  • Received: February 1, 2017
  • Revised: March 4, 2017
  • Accepted: March 28, 2017
  • DOI: 10.5812/gct.14216

To Cite: Tahervand A, Parnian B, Habibi Roudkenar M, Mohammadi Roushandeh A. Digoxin Effectively Inhibited Cell Growth and Induced Senescence in Cervical Cancer Cell Line, Gene Cell Tissue. 2017 ; 4(2):e14216. doi: 10.5812/gct.14216.

Abstract
Copyright © 2017, Gene, Cell and Tissue. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
Acknowledgements
Footnote
References
  • 1. Khaizil Emylia Z, Nik Aina SNZ, Mohd Dasuki S. Preliminary study on anti-proliferative activity of methanolic extract of nephelium lappaceum peels towards breast (MDA-MB-231), cervical (HeLa) and osteosarcoma (MG-63) cancer cell lines. Health. 2013; 4(2): 66-79
  • 2. Sanda MG, Dunn RL, Michalski J, Sandler HM, Northouse L, Hembroff L, et al. Quality of life and satisfaction with outcome among prostate-cancer survivors. N Engl J Med. 2008; 358(12): 1250-61[DOI][PubMed]
  • 3. Lin H, Juang JL, Wang PS. Involvement of Cdk5/p25 in digoxin-triggered prostate cancer cell apoptosis. J Biol Chem. 2004; 279(28): 29302-7[DOI][PubMed]
  • 4. Semenza GL. Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Trends Pharmacol Sci. 2012; 33(4): 207-14[DOI][PubMed]
  • 5. Menger L, Vacchelli E, Kepp O, Eggermont A, Tartour E, Zitvogel L, et al. Trial watch: Cardiac glycosides and cancer therapy. Oncoimmunology. 2013; 2(2)[DOI][PubMed]
  • 6. Colditz GA, Hankinson SE, Hunter DJ, Willett WC, Manson JE, Stampfer MJ, et al. The use of estrogens and progestins and the risk of breast cancer in postmenopausal women. N Engl J Med. 1995; 332(24): 1589-93[DOI][PubMed]
  • 7. Boursi B, Haynes K, Mamtani R, Yang YX. Digoxin use and the risk for colorectal cancer. Pharmacoepidemiol Drug Saf. 2014; 23(11): 1147-53[DOI][PubMed]
  • 8. Ahern TP, Tamimi RM, Rosner BA, Hankinson SE. Digoxin use and risk of invasive breast cancer: evidence from the Nurses' Health Study and meta-analysis. Breast Cancer Res Treat. 2014; 144(2): 427-35[DOI][PubMed]
  • 9. Flahavan EM, Sharp L, Bennett K, Barron TI. A cohort study of digoxin exposure and mortality in men with prostate cancer. BJU Int. 2014; 113(2): 236-45[DOI][PubMed]
  • 10. Lu GY, Liu ST, Huang SM, Chang YL, Lin WS. Multiple effects of digoxin on subsets of cancer-associated genes through the alternative splicing pathway. Biochimie. 2014; 106: 131-9[DOI][PubMed]
  • 11. Campisi J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell. 2005; 120(4): 513-22[DOI][PubMed]
  • 12. Collado M, Blasco MA, Serrano M. Cellular senescence in cancer and aging. Cell. 2007; 130(2): 223-33[DOI][PubMed]
  • 13. DiDomenico RJ, Bress AP, Na-Thalang K, Tsao YY, Groo VL, Deyo KL, et al. Use of a simplified nomogram to individualize digoxin dosing versus standard dosing practices in patients with heart failure. Pharmacotherapy. 2014; 34(11): 1121-31[DOI][PubMed]
  • 14. Dimas K, Papadopoulou N, Baskakis C, Prousis KC, Tsakos M, Alkahtani S, et al. Steroidal cardiac Na+/K+ ATPase inhibitors exhibit strong anti-cancer potential in vitro and in prostate and lung cancer xenografts in vivo. Anticancer Agents Med Chem. 2014; 14(5): 762-70[DOI][PubMed]
  • 15. Riganti C, Campia I, Polimeni M, Pescarmona G, Ghigo D, Bosia A. Digoxin and ouabain induce P-glycoprotein by activating calmodulin kinase II and hypoxia-inducible factor-1alpha in human colon cancer cells. Toxicol Appl Pharmacol. 2009; 240(3): 385-92[DOI][PubMed]
  • 16. Zhao Y, Zhu C, Li X, Zhang Z, Yuan Y, Ni Y, et al. Asterosaponin 1 induces endoplasmic reticulum stress-associated apoptosis in A549 human lung cancer cells. Oncol Rep. 2011; 26(4): 919-24[DOI][PubMed]
  • 17. Nasri HR, Shahouzehi B, Masoumi-Ardakani Y, Iranpour M. Effects of digoxin on cardiac iron content in rat model of iron overload. ARYA Atheroscler. 2016; 12(4): 180-4[PubMed]
  • 18. Winnicka K, Bielawski K, Bielawska A. Cardiac glycosides in cancer research and cancer therapy. Acta Pol Pharm. 2006; 63(2): 109-15[PubMed]
  • 19. Lopez-Lazaro M, Pastor N, Azrak SS, Ayuso MJ, Austin CA, Cortes F. Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients. J Nat Prod. 2005; 68(11): 1642-5[DOI][PubMed]
  • 20. Xu ZW, Wang FM, Gao MJ, Chen XY, Hu WL, Xu RC. Targeting the Na(+)/K(+)-ATPase alpha1 subunit of hepatoma HepG2 cell line to induce apoptosis and cell cycle arresting. Biol Pharm Bull. 2010; 33(5): 743-51[DOI][PubMed]
  • 21. Babula P, Masarik M, Adam V, Provaznik I, Kizek R. From Na+/K+-ATPase and cardiac glycosides to cytotoxicity and cancer treatment. Anticancer Agents Med Chem. 2013; 13(7): 1069-87[PubMed]
  • 22. Semenza GL. HIF-1 and tumor progression: pathophysiology and therapeutics. Trends Mol Med. 2002; 8(4 Suppl)-7[PubMed]
  • 23. Gilkes DM, Semenza GL. Role of hypoxia-inducible factors in breast cancer metastasis. Future Oncol. 2013; 9(11): 1623-36[DOI][PubMed]
  • 24. Biggar RJ, Wohlfahrt J, Melbye M. Digoxin use and the risk of cancers of the corpus uteri, ovary and cervix. Int J Cancer. 2012; 131(3): 716-21[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments