Gene, Cell and Tissue

Published by: Kowsar

The Relationship Between Cigarette Smoking, NOS3 Gene T-786→C Polymorphism, and Diabetic Nephropathy

Sayed Alireza Mirsane 1 , 2 , * , Shima Shafagh 3 and Nasrin Oraei 4
Authors Information
1 Genetic Sciences Student, Qom, IR Iran
2 Surgical Technologist, Kashan University of Medical Sciences, Kashan, Iran
3 General Surgery Specialist, Kashan University of Medical Sciences, Kashan, Iran
4 Lecturer of Islamic Sciences, Education office, Esfahan, Iran
Article information
  • Gene, Cell and Tissue: April 2017, 4 (2); e45302
  • Published Online: April 30, 2017
  • Article Type: Letter
  • Received: June 3, 2017
  • Revised: February 24, 2017
  • Accepted: April 1, 2017
  • DOI: 10.5812/gct.45302

To Cite: Mirsane S A, Shafagh S, Oraei N. The Relationship Between Cigarette Smoking, NOS3 Gene T-786→C Polymorphism, and Diabetic Nephropathy, Gene Cell Tissue. 2017 ; 4(2):e45302. doi: 10.5812/gct.45302.

Copyright © 2017, Zahedan University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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  • 2. Shoukry A, Shalaby SM, Abdelazim S, Abdelazim M, Ramadan A, Ismail MI, et al. Endothelial nitric oxide synthase gene polymorphisms and the risk of diabetic nephropathy in type 2 diabetes mellitus. Genet Test Mol Biomarkers. 2012; 16(6): 574-9[DOI][PubMed]
  • 3. Misiak B, Krolik M, Kukowka A, Lewera A, Leszczynski P, Stankiewicz-Olczyk J, et al. The Role of -786T/C Polymorphism in the Endothelial Nitric Oxide Synthase Gene in Males with Clinical and Biochemical Features of the Metabolic Syndrome. Int J Endocrinol. 2011; 2011: 458750[DOI][PubMed]
  • 4. Ahluwalia TS, Ahuja M, Rai TS, Kohli HS, Sud K, Bhansali A, et al. Endothelial nitric oxide synthase gene haplotypes and diabetic nephropathy among Asian Indians. Mol Cell Biochem. 2008; 314(1-2): 9-17[DOI][PubMed]
  • 5. Asakimori Y, Yorioka N, Taniguchi Y, Ito T, Ogata S, Kyuden Y, et al. T(-786)-->C polymorphism of the endothelial nitric oxide synthase gene influences the progression of renal disease. Nephron. 2002; 91(4): 747-51[DOI][PubMed]
  • 6. He Y, Fan Z, Zhang J, Zhang Q, Zheng M, Li Y, et al. Polymorphisms of eNOS gene are associated with diabetic nephropathy: a meta-analysis. Mutagenesis. 2011; 26(2): 339-49[DOI][PubMed]
  • 7. Mooyaart AL, Valk EJ, van Es LA, Bruijn JA, de Heer E, Freedman BI, et al. Genetic associations in diabetic nephropathy: a meta-analysis. Diabetologia. 2011; 54(3): 544-53[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

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