Gene, Cell and Tissue

Published by: Kowsar

Metabolic Syndrome and Mitochondrial Transcription Factor A

Marijana Tadic 1 , * and Cesare Cuspidi 2
Authors Information
1 University Hospital Center “Dr. Dragisa Misovic”, Belgrade, Serbia
2 Italian Auxologico Institute, Clinical Research Unit, University of Milan-Bicocca, Meda, Italy
Article information
  • Gene, Cell and Tissue: July 01, 2014, 1 (2); e20664
  • Published Online: June 24, 2014
  • Article Type: Letter
  • Received: May 25, 2014
  • Revised: June 3, 2014
  • Accepted: June 8, 2014
  • DOI: 10.17795/gct-20664

To Cite: Tadic M, Cuspidi C. Metabolic Syndrome and Mitochondrial Transcription Factor A, Gene Cell Tissue. 2014 ; 1(2):e20664. doi: 10.17795/gct-20664.

Copyright © 2014, Zahedan University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
  • 1. Kusminski CM, Scherer PE. Mitochondrial dysfunction in white adipose tissue. Trends Endocrinol Metab. 2012; 23(9): 435-43[DOI][PubMed]
  • 2. Choi YS, Kim S, Pak YK. Mitochondrial transcription factor A (mtTFA) and diabetes. Diabetes Res Clin P. 2001; 54-9[DOI]
  • 3. Vernochet C, McDonald ME, Farmer SR. Brown adipose tissue: a promising target to combat obesity. Drug News Perspect. 2010; 23(7): 409-17[DOI][PubMed]
  • 4. Vernochet C, Mourier A, Bezy O, Macotela Y, Boucher J, Rardin MJ, et al. Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance. Cell Metab. 2012; 16(6): 765-76[DOI][PubMed]
  • 5. Santos JM, Kowluru RA. Impaired transport of mitochondrial transcription factor A (TFAM) and the metabolic memory phenomenon associated with the progression of diabetic retinopathy. Diabetes Metab Res Rev. 2013; 29(3): 204-13[DOI][PubMed]
  • 6. Wang CH, Wang CC, Huang HC, Wei YH. Mitochondrial dysfunction leads to impairment of insulin sensitivity and adiponectin secretion in adipocytes. FEBS J. 2013; 280(4): 1039-50[DOI][PubMed]
  • 7. Holmstrom MH, Iglesias-Gutierrez E, Zierath JR, Garcia-Roves PM. Tissue-specific control of mitochondrial respiration in obesity-related insulin resistance and diabetes. Am J Physiol Endocrinol Metab. 2012; 302(6)-9[DOI][PubMed]
  • 8. Hashemi M, Rezaei H, Ali Kaykhaei M, Taheri M. Association of the Promoter Methylation of Mitochondrial Transcription Factor A With Susceptibility to Metabolic Syndrome. Gene Cell Tissue. 2014; 1(1)
  • 9. Ikeuchi M, Matsusaka H, Kang D, Matsushima S, Ide T, Kubota T, et al. Overexpression of mitochondrial transcription factor a ameliorates mitochondrial deficiencies and cardiac failure after myocardial infarction. Circulation. 2005; 112(5): 683-90[DOI][PubMed]
  • 10. Colom B, Oliver J, Garcia-Palmer FJ. Sexual Dimorphism in the Alterations of Cardiac Muscle Mitochondrial Bioenergetics Associated to the Ageing Process. J Gerontol A Biol Sci Med Sci. 2014; [DOI][PubMed]
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