Gene, Cell and Tissue

Published by: Kowsar

Effect of MTHFR C677T Polymorphism on Methylation Status of E-Cadherin in Gastric Cancer

Ahmad Shabanizadeh 1 , Mohammad Mohsen Taghavi 1 , Mahdi Shariati Kohbanani 1 , Zahra Taghipour 1 , Hamidreza Jafarinaveh 1 , Akram Mollahosseni 1 , Mohammad Reza Salahshoor 2 , * and Cyrus Jalili 2
Authors Information
1 Department of Anatomy, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, IR Iran
2 Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, IR Iran
Article information
  • Gene, Cell and Tissue: October 01, 2016, 3 (4); e38267
  • Published Online: August 2, 2016
  • Article Type: Research Article
  • Received: June 25, 2016
  • Revised: July 20, 2016
  • Accepted: July 23, 2016
  • DOI: 10.17795/gct-38267

To Cite: Shabanizadeh A, Taghavi M M, Shariati Kohbanani M, Taghipour Z, Jafarinaveh H, et al. Effect of MTHFR C677T Polymorphism on Methylation Status of E-Cadherin in Gastric Cancer, Gene Cell Tissue. 2016 ; 3(4):e38267. doi: 10.17795/gct-38267.

Abstract
Copyright © 2016, Zahedan University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
Acknowledgements
Footnote
References
  • 1. Gramatikova S, Hazlewood G, Lam D, Barton NR, Sturgis BG, Robertson DE. Phospholipases, nucleic acids encoding them and methods for making and using them 2011;
  • 2. Kolahdoozan S, Sadjadi A, Radmard AR, Khademi H. Five common cancers in Iran. Arch Iran Med. 2010; 13(2): 143-6[PubMed]
  • 3. An C, Choi IS, Yao JC, Worah S, Xie K, Mansfield PF, et al. Prognostic significance of CpG island methylator phenotype and microsatellite instability in gastric carcinoma. Clin Cancer Res. 2005; 11(2 Pt 1): 656-63[PubMed]
  • 4. Gudmundsdottir K, Ashworth A. The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability. Oncogene. 2006; 25(43): 5864-74[DOI][PubMed]
  • 5. Buschke S, Stark HJ, Cerezo A, Pratzel-Wunder S, Boehnke K, Kollar J, et al. A decisive function of transforming growth factor-beta/Smad signaling in tissue morphogenesis and differentiation of human HaCaT keratinocytes. Mol Biol Cell. 2011; 22(6): 782-94[DOI][PubMed]
  • 6. Baldwin RL, Nemeth E, Tran H, Shvartsman H, Cass I, Narod S, et al. BRCA1 promoter region hypermethylation in ovarian carcinoma: a population-based study. Cancer Res. 2000; 60(19): 5329-33[PubMed]
  • 7. Niessen CM, Gumbiner BM. Cadherin-mediated cell sorting not determined by binding or adhesion specificity. J Cell Biol. 2002; 156(2): 389-99[DOI][PubMed]
  • 8. Das PM, Singal R. DNA methylation and cancer. J Clin Oncol. 2004; 22(22): 4632-42[DOI][PubMed]
  • 9. Lin J, Spitz MR, Wang Y, Schabath MB, Gorlov IP, Hernandez LM, et al. Polymorphisms of folate metabolic genes and susceptibility to bladder cancer: a case-control study. Carcinogenesis. 2004; 25(9): 1639-47[DOI][PubMed]
  • 10. Langevin SM, Lin D, Matsuo K, Gao CM, Takezaki T, Stolzenberg-Solomon RZ, et al. Review and pooled analysis of studies on MTHFR C677T polymorphism and esophageal cancer. Toxicol Lett. 2009; 184(2): 73-80[DOI][PubMed]
  • 11. Maruti SS, Ulrich CM, Jupe ER, White E. MTHFR C677T and postmenopausal breast cancer risk by intakes of one-carbon metabolism nutrients: a nested case-control study. Breast Cancer Res. 2009; 11(6): 91[DOI][PubMed]
  • 12. Salehi R, Tabanifar B, Asgarani E, Faghihi M, Allame T. An efficient method for DNA extraction from paraffin wax embedded tissues for PCR amplification of human and viral DNA. Iranian J Pathol. 2008; 3(4): 173-8
  • 13. Innis MA, Gelfand DH, Sninsky JJ, White TJ. PCR protocols: a guide to methods and applications. 2012;
  • 14. Clark SJ, Melki J. DNA methylation and gene silencing in cancer: which is the guilty party? Oncogene. 2002; 21(35): 5380-7[DOI][PubMed]
  • 15. Pepe C, Guidugli L, Sensi E, Aretini P, D'Andrea E, Montagna M, et al. Methyl group metabolism gene polymorphisms as modifier of breast cancer risk in Italian BRCA1/2 carriers. Breast Cancer Res Treat. 2007; 103(1): 29-36[DOI][PubMed]
  • 16. Chou YC, Wu MH, Yu JC, Lee MS, Yang T, Shih HL, et al. Genetic polymorphisms of the methylenetetrahydrofolate reductase gene, plasma folate levels and breast cancer susceptibility: a case-control study in Taiwan. Carcinogenesis. 2006; 27(11): 2295-300[DOI][PubMed]
  • 17. Shrubsole MJ, Gao YT, Cai Q,, Shu XO, Dai Q,, Hébert JR. MTHFR polymorphisms, dietary folate intake, and breast cancer risk results from the Shanghai Breast Cancer Study. Cancer Epidemiology Biomarkers & Prevention. 2004; 13(2): 190-6
  • 18. Terry KL, Tworoger SS, Goode EL, Gates MA, Titus-Ernstoff L, Kelemen LE, et al. MTHFR polymorphisms in relation to ovarian cancer risk. Gynecol Oncol. 2010; 119(2): 319-24[DOI][PubMed]
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