Gene, Cell and Tissue

Published by: Kowsar

Trophoblast Giant Cells, the Prime Suspects of Deficient Placentation Associated With Pregnancy Complications

Zahra Heidari 1 , 2 and Nadia Sheibak 2 , *
Authors Information
1 Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan, IR Iran
2 Department of Histology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, IR Iran
Article information
  • Gene, Cell and Tissue: April 01, 2016, 3 (2); e38516
  • Published Online: April 27, 2016
  • Article Type: Editorial
  • Received: April 16, 2016
  • Revised: April 24, 2016
  • Accepted: April 24, 2016
  • DOI: 10.17795/gct-38516

To Cite: Heidari Z, Sheibak N. Trophoblast Giant Cells, the Prime Suspects of Deficient Placentation Associated With Pregnancy Complications, Gene Cell Tissue. 2016 ; 3(2):e38516. doi: 10.17795/gct-38516.

Copyright © 2016, Zahedan University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
  • 1. Heidari Z, Mahmoudzadeh-Sagheb H, Zakeri Z, Nourzaei N. Stereological changes of human placenta in systemic lupus erythematosus compared with healthy controls. Zahedan J Res Med Sci. 2013; 15(7): 50-4
  • 2. Heidari Z, Sakhavar N, Mahmoudzadeh-Sagheb H, Ezazi-Bojnourdi T. Stereological analysis of human placenta in cases of placenta previa in comparison with normally implanted controls. J Reprod Infertil. 2015; 16(2): 90-5[PubMed]
  • 3. Komatsu D, Abe T, Sano Y, Shimazaki K, Tomita M, Kanayama N, et al. Increase of the trophoblast giant cells with prolactin-releasing peptide (PrRP) receptor expression in p53-null mice. Mol Reprod Dev. 2007; 74(9): 1089-94[DOI][PubMed]
  • 4. Quenby S, Mountfield S, Cartwright JE, Whitley GS, Chamley L, Vince G. Antiphospholipid antibodies prevent extravillous trophoblast differentiation. Fertil Steril. 2005; 83(3): 691-8[DOI][PubMed]
  • 5. Lyall F. Mechanisms regulating cytotrophoblast invasion in normal pregnancy and pre-eclampsia. Aust N Z J Obstet Gynaecol. 2006; 46(4): 266-73[DOI][PubMed]
  • 6. Hu D, Cross JC. Development and function of trophoblast giant cells in the rodent placenta. Int J Dev Biol. 2010; 54(2-3): 341-54[DOI][PubMed]
  • 7. Soloveva V, Linzer DI. Differentiation of placental trophoblast giant cells requires downregulation of p53 and Rb. Placenta. 2004; 25(1): 29-36[DOI][PubMed]
  • 8. Redman CW, Staff AC. Preeclampsia, biomarkers, syncytiotrophoblast stress, and placental capacity. Am J Obstetric Gynecol. 2015; 213(4)-4
  • 9. Quenby S, Brazeau C, Drakeley A, Lewis-Jones DI, Vince G. Oncogene and tumour suppressor gene products during trophoblast differentiation in the first trimester. Mol Hum Reprod. 1998; 4(5): 477-81[PubMed]
  • 10. Burrows TD, King A, Loke YW. Trophoblast migration during human placental implantation. Hum Reprod Update. 1996; 2(4): 307-21[PubMed]
  • 11. Surita FGC, Parpinelli MA, Yonehara E, Krupa F, Cecatti JG. Systemic lupus erythematosus and pregnancy: clinical evolution, maternal and perinatal outcomes and placental findings. Sao Paulo Med J. 2007; 125(2): 91-5[DOI]
  • 12. Ostensen M, Clowse M. Pathogenesis of pregnancy complications in systemic lupus erythematosus. Curr Opin Rheumatol. 2013; 25(5): 591-6[DOI][PubMed]
  • 13. Chauhan R, Handa R, Das TP, Pati U. Over-expression of TATA binding protein (TBP) and p53 and autoantibodies to these antigens are features of systemic sclerosis, systemic lupus erythematosus and overlap syndromes. Clin Exp Immunol. 2004; 136(3): 574-84[DOI][PubMed]
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