Gene, Cell and Tissue

Published by: Kowsar

Association of Leptin Receptor Gene Gln223Arg and lys109Arg Polymorphisms with Obesity and Overweight in an Iranian Young Population

Fereshteh Farzam 1 , Sanaz Mahmazi 2 , * and Javad Nasseryan 3
Authors Information
1 Department of Genetics, Faculty of Basic Sciences, Islamic Azad University, Zanjan Branch, Zanjan, Iran
2 Department of Genetics, Biology Research Center, Zanjan Branch, Islamic Azad University, Zanjan, Iran
3 Department of Statistical and Mathematics, Faculty of Basic Sciences, Islamic Azad University, Zanjan Branch, Zanjan, Iran
Article information
  • Gene, Cell and Tissue: July 2017, 4 (3); e57937
  • Published Online: July 31, 2017
  • Article Type: Research Article
  • Received: November 12, 2016
  • Revised: April 10, 2017
  • Accepted: July 5, 2017
  • DOI: 10.5812/gct.57937

To Cite: Farzam F, Mahmazi S, Nasseryan J. Association of Leptin Receptor Gene Gln223Arg and lys109Arg Polymorphisms with Obesity and Overweight in an Iranian Young Population, Gene Cell Tissue. 2017 ; 4(3):e57937. doi: 10.5812/gct.57937.

Copyright © 2017, Gene, Cell and Tissue. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Chabowska-Kita A, Kozak LP. The critical period for brown adipocyte development: Genetic and environmental influences. Obesity (Silver Spring). 2016;24(2):283-90. doi: 10.1002/oby.21376. [PubMed: 26813522].
  • 2. Fan SH, Say YH. Leptin and leptin receptor gene polymorphisms and their association with plasma leptin levels and obesity in a multi-ethnic Malaysian suburban population. J Physiol Anthropol. 2014;33:15. doi: 10.1186/1880-6805-33-15. [PubMed: 24947733].
  • 3. Gale SM, Castracane VD, Mantzoros CS. Energy homeostasis, obesity and eating disorders: recent advances in endocrinology. J Nutr. 2004;134(2):295-8. [PubMed: 14747663].
  • 4. Tartaglia LA. The leptin receptor. J Biol Chem. 1997;272(10):6093-6. doi: 10.1074/jbc.272.10.6093. [PubMed: 9102398].
  • 5. Lopez M. Hypothalamic Leptin Resistance: From BBB to BBSome. PLoS Genet. 2016;12(5). e1005980. doi: 10.1371/journal.pgen.1005980. [PubMed: 27149508].
  • 6. Jing X, Ou C, Chen H, Wang T, Xu B, Lu S, et al. Electroacupuncture Reduces Weight Gain Induced by Rosiglitazone through PPARgamma and Leptin Receptor in CNS. Evid Based Complement Alternat Med. 2016;2016:8098561. doi: 10.1155/2016/8098561. [PubMed: 26904147].
  • 7. Rehman Khan A, Awan FR. Leptin Resistance: A Possible Interface Between Obesity and Pulmonary-Related Disorders. Int J Endocrinol Metab. 2016;14(1). e32586. doi: 10.5812/ijem.32586. [PubMed: 27279832].
  • 8. Jacobs DT, Silva LM, Allard BA, Schonfeld MP, Chatterjee A, Talbott GC, et al. Dysfunction of intraflagellar transport-A causes hyperphagia-induced obesity and metabolic syndrome. Dis Model Mech. 2016;9(7):789-98. doi: 10.1242/dmm.025791. [PubMed: 27482817].
  • 9. Sun Y, Yang Y, Qin Z, Cai J, Guo X, Tang Y, et al. The Acute-Phase Protein Orosomucoid Regulates Food Intake and Energy Homeostasis via Leptin Receptor Signaling Pathway. Diabetes. 2016;65(6):1630-41. doi: 10.2337/db15-1193. [PubMed: 27207522].
  • 10. Nabi T, Rafiq N, Qayoom O. Leptin dysfunction: A cause for obesity. Int J Health Sci. 2016;6(1):498-505.
  • 11. Marroqui L, Gonzalez A, Neco P, Caballero-Garrido E, Vieira E, Ripoll C, et al. Role of leptin in the pancreatic beta-cell: effects and signaling pathways. J Mol Endocrinol. 2012;49(1):R9-17. doi: 10.1530/JME-12-0025. [PubMed: 22448029].
  • 12. Klok MD, Jakobsdottir S, Drent ML. The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review. Obes Rev. 2007;8(1):21-34. doi: 10.1111/j.1467-789X.2006.00270.x. [PubMed: 17212793].
  • 13. Komsu-Ornek Z, Demirel F, Dursun A, Ermis B, Piskin E, Bideci A. Leptin receptor gene Gln223Arg polymorphism is not associated with obesity and metabolic syndrome in Turkish children. Turk J Pediatr. 2012;54(1):20-4. [PubMed: 22397037].
  • 14. Marginean CO, Marginean C, Voidazan S, Melit L, Crauciuc A, Duicu C, et al. Correlations Between Leptin Gene Polymorphisms 223 A/G, 1019 G/A, 492 G/C, 976 C/A, and Anthropometrical and Biochemical Parameters in Children With Obesity: A Prospective Case-Control Study in a Romanian Population-The Nutrichild Study. Medicine (Baltimore). 2016;95(12). e3115. doi: 10.1097/MD.0000000000003115. [PubMed: 27015185].
  • 15. Linjawi SAM, Al-Harbi SMA. Impact of leptin receptor gene LYS109ARG polymorphism on obesity in jeddah city. Life Sci J. 2014;11(7).
  • 16. Williams EP, Mesidor M, Winters K, Dubbert PM, Wyatt SB. Overweight and Obesity: Prevalence, Consequences, and Causes of a Growing Public Health Problem. Curr Obes Rep. 2015;4(3):363-70. doi: 10.1007/s13679-015-0169-4. [PubMed: 26627494].
  • 17. Hastuti P, Zukhrufia I, Padwaswari MH, Nuraini A, Sadewa AH. Polymorphism in leptin receptor gene was associated with obesity in Yogyakarta, Indonesia. Egypt J Med Hum Genet. 2016;17(3):271-6. doi: 10.1016/j.ejmhg.2015.12.011.
  • 18. Rojano-Rodriguez ME, Beristain-Hernandez JL, Zavaleta-Villa B, Maravilla P, Romero-Valdovinos M, Olivo-Diaz A. Leptin receptor gene polymorphisms and morbid obesity in Mexican patients. Hereditas. 2016;153:2. doi: 10.1186/s41065-016-0006-0. [PubMed: 28096764].
  • 19. Oliveira R, Cerda A, Genvigir FD, Sampaio MF, Armaganijan D, Bernik MM, et al. Leptin receptor gene polymorphisms are associated with adiposity and metabolic alterations in Brazilian individuals. Arq Bras Endocrinol Metabol. 2013;57(9):677-84. [PubMed: 24402012].

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