Gene, Cell and Tissue

Published by: Kowsar

Thalassemia Spectrum and Prenatal Diagnosis among Voluntary Couples in Shushtar City, during a Five Year Period

Masoomeh Sayahi 1 , Farideh Ghanbari Mardasi 1 , * and Masoomeh Salehi Kambo 2
Authors Information
1 Department of Midwifery, Shoushtar Faculty of Medical Sciences, Shoushtar, IR Iran
2 Department of Nursing, Shoushtar Faculty of Medical Sciences, Shoushtar, IR Iran
Article information
  • Gene, Cell and Tissue: October 2017, 4 (4); e64501
  • Published Online: October 31, 2017
  • Article Type: Research Article
  • Received: August 25, 2017
  • Revised: September 25, 2017
  • Accepted: October 5, 2017
  • DOI: 10.5812/gct.64501

To Cite: Sayahi M, Ghanbari Mardasi F, Salehi Kambo M. Thalassemia Spectrum and Prenatal Diagnosis among Voluntary Couples in Shushtar City, during a Five Year Period, Gene Cell Tissue. 2017 ; 4(4):e64501. doi: 10.5812/gct.64501.

Abstract
Copyright © 2017, Gene, Cell and Tissue. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Methods
3. Results
4. Discussion
Acknowledgements
References
  • 1. Akhavan-Niaki H, Derakhshandeh-Peykar P, Banihashemi A, Mostafazadeh A, Asghari B, Ahmadifard MR, et al. A comprehensive molecular characterization of beta thalassemia in a highly heterogeneous population. Blood Cells Mol Dis. 2011;47(1):29-32. doi: 10.1016/j.bcmd.2011.03.005. [PubMed: 21493114].
  • 2. Marengo-Rowe AJ. The thalassemias and related disorders. Proc (Bayl Univ Med Cent). 2007;20(1):27-31. [PubMed: 17256039].
  • 3. Saleh-Gohari N, Bazrafshani M. Distribution of beta-Globin Gene Mutations in Thalassemia Minor Population of Kerman Province, Iran. Iran J Public Health. 2010;39(2):69-76. [PubMed: 23113009].
  • 4. Derakhshandeh-Peykar P, Akhavan-Niaki H, Tamaddoni A, Ghawidel-Parsa S, Naieni KH, Rahmani M, et al. Distribution of beta-thalassemia mutations in the northern provinces of Iran. Hemoglobin. 2007;31(3):351-6. doi: 10.1080/03630260701462030. [PubMed: 17654072].
  • 5. Ghotbi N, Tsukatani T. Evaluation of the national health policy of thalassaemia screening in the Islamic Republic of Iran. East Mediterr Health J. 2005;11(3):308-18. [PubMed: 16602449].
  • 6. Sharifi A, Aminzadeh M, Pourmoghadam Z, Mahdieh N. The frequency of common beta-thalassemia mutations among couples referred to health centers of Ilam during a five years period. J Ilam Univ Med Sci. 2014;22(2):17-23.
  • 7. Zandian KH, Nateghi J, Keikhahi B, Pedram M, Hadavi V, Hafezi N. Elucidation of α-thalassemia mutations in Khuzestan, Iran. Gene 3pd Millen. 2007;5(3):1120-5.
  • 8. Globin. Globin gene. 2015. Available from: http://globin.cse.psu.edu.
  • 9. Valizadeh F, Deylami A. Prevalence of mutations of alpha globin gene in suspected alpha carrier couples, Babolsar, 2006-2011. J Mazandaran Univ Med Sci. 2014;23(109):17-25.
  • 10. Nashtahosseini Z, Nazemi A, Keihanian S, Hajihosseini R, Esk M. Frequency of seven common deletion alfa-globins mutation carriers in suspect referred In West Mazandaran, Iran. Electron J Biol. 2016;12(1).
  • 11. Lucarelli G, Gaziev J. Advances in the allogeneic transplantation for thalassemia. Blood Rev. 2008;22(2):53-63. doi: 10.1016/j.blre.2007.10.001. [PubMed: 18039551].
  • 12. Kiani AA, Mortazavi Y, Zeinali S, Shirkhani Y. The molecular analysis of beta-thalassemia mutations in Lorestan Province, Iran. Hemoglobin. 2007;31(3):343-9. doi: 10.1080/03630260701459382. [PubMed: 17654071].
  • 13. Galane R, Cao A. Alpha-Thalassemia. Gene reviews. 2013.
  • 14. Harteveld CL, Yavarian M, Zorai A, Quakkelaar ED, van Delft P, Giordano PC. Molecular spectrum of alpha-thalassemia in the Iranian population of Hormozgan: three novel point mutation defects. Am J Hematol. 2003;74(2):99-103. doi: 10.1002/ajh.10385. [PubMed: 14508795].
  • 15. Tamaddoni A, Hadavi V, Nejad NH, Khosh-Ain A, Siami R, Aghai-Meibodi J, et al. alpha-Thalassemia mutation analyses in Mazandaran province, North Iran. Hemoglobin. 2009;33(2):115-23. doi: 10.1080/03630260902817297. [PubMed: 19373587].
  • 16. Rund D, Rachmilewitz E. Beta-thalassemia. N Engl J Med. 2005;353(11):1135-46. doi: 10.1056/NEJMra050436. [PubMed: 16162884].
  • 17. Patrinos GP, Giardine B, Riemer C, Miller W, Chui DH, Anagnou NP, et al. Improvements in the HbVar database of human hemoglobin variants and thalassemia mutations for population and sequence variation studies. Nucleic Acids Res. 2004;32(Database issue):D537-41. doi: 10.1093/nar/gkh006. [PubMed: 14681476].
  • 18. Cao A, Galanello R. Beta-thalassemia. Genet Med. 2010;12(2):61-76. doi: 10.1097/GIM.0b013e3181cd68ed. [PubMed: 20098328].
  • 19. Sarookhani MR, Ahmadi MH. Rare and unexpected beta thalassemic mutations in Qazvin province of Iran. Afr J Biotechnol. 2010;9(1).
  • 20. Galehdari H, Salehi B, Azmoun S, Keikhaei B, Zandian KM, Pedram M. Comprehensive spectrum of the beta-Thalassemia mutations in Khuzestan, southwest Iran. Hemoglobin. 2010;34(5):461-8. doi: 10.3109/03630269.2010.514153. [PubMed: 20854120].
  • 21. Mortazavi Y, Taheri S, Derakhshandeh J, Zeinali S. Characterization of Beta globin gene mutations in Zanjan province: An Introduction to prenatal diagnosis of thalassemia. ZUMS J. 2008;16(63):1-10.
  • 22. Soteh H, Akhavan Niaki H, Kowsarian M, Aliasgharian A, Banihashemi A. Frequency of Beta-globin gene mutations in beta-thalassemia patients from east of Mazandaran. J Mazandaran Univ Med Sci. 2008;18(67):17-25.
  • 23. Rahim F, Saki N, Jalalai far MA. The role of gene mutations detection in defining the spectrum of ß – thalassemia in various ethnic regions. In human genetic diseases. 2011. doi: 10.5772/24295.
  • 24. Langlois S, Ford JC, Chitayat D, Ccmg Prenatal Diagnosis C, Sogc Genetics C. Carrier screening for thalassemia and hemoglobinopathies in Canada. J Obstet Gynaecol Can. 2008;30(10):950-9. doi: 10.1016/S1701-2163(16)32975-9. [PubMed: 19038079].
  • 25. Zandian K, Keikhaie B, Pedram M, Kianpoor Ghahfarokhi F. Prenatal Diagnosis and Frequency Determination of alpha and beta Thalassemia, S, D, C, and H Hemoglobinopathies Globin Mutational Genes Aanalysis among Voluntary Couples from Ahvaz. Iran J Blood Cancer. 2009;1(3):95-8.
  • 26. Zarbakhsh B, Farshadi E, Ariani Kashani A, Karimipoor M, Azarkeivan A, Habibi Pourfatideh R, et al. Molecular study of alpha-thalassemia mutations in Iranian potential carriers. Sci J Iran Blood Transfus Organ. 2010;7(2):70-7.
  • 27. Zandian K, Nateghi J, Keikhaie B, Pedram M, Hafezi-Nejad N, Hadavi V, et al. alpha-thalassemia mutations in Khuzestan Province, Southwest Iran. Hemoglobin. 2008;32(6):546-52. doi: 10.1080/03630260802532780. [PubMed: 19065332].
  • 28. Neyshabouri M, Abbasi-Moheb L, Kahrizi K, Keyhany E, Najmabad H, Pourfath EAA, et al. Alpha-thalassemia: deletion analysis in Iran. Arch Iran Med. 2001;4:160-4.
  • 29. Karimi M, Yarmohammadi H, Farjadian S, Zeinali S, Moghaddam Z, Cappellini MD, et al. Beta-thalassemia intermedia from southern Iran: IVS-II-1 (G-->A) is the prevalent thalassemia intermedia allele. Hemoglobin. 2002;26(2):147-54. [PubMed: 12144057].
  • 30. Zahed L. The spectrum of β-thalassemia mutations in the Arab populations. BioMed Res Int. 2001;1(3):129-32.
  • 31. Najmabadi H, Karimi-Nejad R, Sahebjam S, Pourfarzad F, Teimourian S, Sahebjam F, et al. The beta-thalassemia mutation spectrum in the Iranian population. Hemoglobin. 2001;25(3):285-96. [PubMed: 11570721].

Featured Image:

Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments