Gene, Cell and Tissue

Published by: Kowsar

Association Study of rs763780T>C IL-17F and rs2275913G>A IL-17A Polymorphisms with Breast Cancer Risk in East Azerbaijan-Iran

Elnaz Aghayi 1 , Nazila Moghtaran Bonab 1 , * and Zahra Hojjati Bonab 1
Authors Information
1 Department of Molecular Biology, Bonab Branch, Islamic Azad University, Bonab, Iran
Article information
  • Gene, Cell and Tissue: July 2018, 5 (3); e84483
  • Published Online: November 4, 2018
  • Article Type: Research Article
  • Received: September 22, 2018
  • Accepted: October 23, 2018
  • DOI: 10.5812/gct.84483

To Cite: Aghayi E, Moghtaran Bonab N , Hojjati Bonab Z . Association Study of rs763780T>C IL-17F and rs2275913G>A IL-17A Polymorphisms with Breast Cancer Risk in East Azerbaijan-Iran, Gene Cell Tissue. 2018 ; 5(3):e84483. doi: 10.5812/gct.84483.

Copyright © 2018, Gene, Cell and Tissue. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010;127(12):2893-917. doi: 10.1002/ijc.25516. [PubMed: 21351269].
  • 2. Jafarzadeh A, Minaee K, Farsinejad AR, Nemati M, Khosravimashizi A, Daneshvar H, et al. Evaluation of the circulating levels of IL-12 and IL-33 in patients with breast cancer: Influences of the tumor stages and cytokine gene polymorphisms. Iran J Basic Med Sci. 2015;18(12):1189-98. [PubMed: 26877848]. [PubMed Central: PMC4744358].
  • 3. Soheilyfar S, Velashjerdi Z, Sayed Hajizadeh Y, Fathi Maroufi N, Amini Z, Khorrami A, et al. In vivo and in vitro impact of miR-31 and miR-143 on the suppression of metastasis and invasion in breast cancer. JBUON. 2018;23(5):1290-6.
  • 4. Niu YM, Yuan H, Zhou Y. Interleukin-17 gene polymorphisms contribute to cancer risk. Mediat Inflamm. 2014;2014:1-9. doi: 10.1155/2014/128490.
  • 5. Yang B, Kang H, Fung A, Zhao H, Wang T, Ma D. The role of interleukin 17 in tumour proliferation, angiogenesis, and metastasis. Mediat Inflamm. 2014;2014:1-12. doi: 10.1155/2014/623759.
  • 6. Alexandrakis MG, Pappa CA, Miyakis S, Sfiridaki A, Kafousi M, Alegakis A, et al. Serum interleukin-17 and its relationship to angiogenic factors in multiple myeloma. Eur J Intern Med. 2006;17(6):412-6. doi: 10.1016/j.ejim.2006.02.012. [PubMed: 16962948].
  • 7. Zhu X, Mulcahy LA, Mohammed RA, Lee AH, Franks HA, Kilpatrick L, et al. IL-17 expression by breast-cancer-associated macrophages: IL-17 promotes invasiveness of breast cancer cell lines. Breast Cancer Res. 2008;10(6):R95. doi: 10.1186/bcr2195. [PubMed: 19014637]. [PubMed Central: PMC2656888].
  • 8. Quan Y, Zhou B, Wang Y, Duan R, Wang K, Gao Q, et al. Association between IL17 polymorphisms and risk of cervical cancer in Chinese women. Clin Dev Immunol. 2012;2012:258293. doi: 10.1155/2012/258293. [PubMed: 23049595]. [PubMed Central: PMC3463183].
  • 9. Wu D, Wu P, Huang Q, Liu Y, Ye J, Huang J. Interleukin-17: A promoter in colorectal cancer progression. Clin Dev Immunol. 2013;2013:436307. doi: 10.1155/2013/436307. [PubMed: 24382972]. [PubMed Central: PMC3870650].
  • 10. Bastid J, Bonnefoy N, Eliaou JF, Bensussan A. Lymphocyte-derived interleukin-17A adds another brick in the wall of inflammation-induced breast carcinogenesis. Oncoimmunology. 2014;3. e28273. doi: 10.4161/onci.28273. [PubMed: 25050201]. [PubMed Central: PMC4063083].
  • 11. Kolls JK, Linden A. Interleukin-17 family members and inflammation. Immunity. 2004;21(4):467-76. doi: 10.1016/j.immuni.2004.08.018. [PubMed: 15485625].
  • 12. Kawaguchi M, Adachi M, Oda N, Kokubu F, Huang SK. IL-17 cytokine family. J Allergy Clin Immunol. 2004;114(6):1265-73. quiz 1274. doi: 10.1016/j.jaci.2004.10.019. [PubMed: 15577820].
  • 13. Kawaguchi M, Onuchic LF, Li XD, Essayan DM, Schroeder J, Xiao HQ, et al. Identification of a novel cytokine, ML-1, and its expression in subjects with asthma. J Immunol. 2001;167(8):4430-5. [PubMed: 11591768].
  • 14. Paradowska-Gorycka A, Wojtecka-Lukasik E, Trefler J, Wojciechowska B, Lacki JK, Maslinski S. Association between IL-17F gene polymorphisms and susceptibility to and severity of rheumatoid arthritis (RA). Scand J Immunol. 2010;72(2):134-41. doi: 10.1111/j.1365-3083.2010.02411.x. [PubMed: 20618772].
  • 15. Chen B, Zeng Z, Hou J, Chen M, Gao X, Hu P. Association of interleukin-17F 7488 single nucleotide polymorphism and inflammatory bowel disease in the Chinese population. Scand J Gastroenterol. 2009;44(6):720-6. doi: 10.1080/00365520902795430. [PubMed: 19263269].
  • 16. Seiderer J, Elben I, Diegelmann J, Glas J, Stallhofer J, Tillack C, et al. Role of the novel Th17 cytokine IL-17F in inflammatory bowel disease (IBD): Upregulated colonic IL-17F expression in active Crohn's disease and analysis of the IL17F p.His161Arg polymorphism in IBD. Inflamm Bowel Dis. 2008;14(4):437-45. doi: 10.1002/ibd.20339. [PubMed: 18088064].
  • 17. Liu S, Xiong YZ, Li T, Li Y, Gu SQ, Wang YM, et al. Interleukin-17A and -17F gene polymorphisms in Chinese population with chronic immune thrombocytopenia. Ann Clin Lab Sci. 2016;46(3):291-7. [PubMed: 27312555].
  • 18. Xu BL, Li YT, Dong SX, Qi J, Feng HM, Zi L, et al. IL-17 rs2275913 genetic variation contributes to the development of gastric cancer in a Chinese population. Genet Mol Res. 2016;15(2). doi: 10.4238/gmr.15027756. [PubMed: 27323118].
  • 19. Cole SW. Chronic inflammation and breast cancer recurrence. J Clin Oncol. 2009;27(21):3418-9. doi: 10.1200/JCO.2009.21.9782. [PubMed: 19470918]. [PubMed Central: PMC4828958].
  • 20. Cabodi S, Taverna D. Interfering with inflammation: A new strategy to block breast cancer self-renewal and progression? Breast Cancer Res. 2010;12(2):305. doi: 10.1186/bcr2563. [PubMed: 20459595]. [PubMed Central: PMC2879570].
  • 21. Dong LM, Potter JD, White E, Ulrich CM, Cardon LR, Peters U. Genetic susceptibility to cancer: The role of polymorphisms in candidate genes. JAMA. 2008;299(20):2423-36. doi: 10.1001/jama.299.20.2423. [PubMed: 18505952]. [PubMed Central: PMC2772197].
  • 22. Omrane I, Marrakchi R, Baroudi O, Mezlini A, Ayari H, Medimegh I, et al. Significant association between interleukin-17A polymorphism and colorectal cancer. Tumour Biol. 2014;35(7):6627-32. doi: 10.1007/s13277-014-1890-4. [PubMed: 24699997].
  • 23. Wrobel T, Gebura K, Wysoczanska B, Jazwiec B, Dobrzynska O, Mazur G, et al. IL-17F gene polymorphism is associated with susceptibility to acute myeloid leukemia. J Cancer Res Clin Oncol. 2014;140(9):1551-5. doi: 10.1007/s00432-014-1674-7. [PubMed: 24793548]. [PubMed Central: PMC4131129].
  • 24. Zhou B, Zhang P, Wang Y, Shi S, Zhang K, Liao H, et al. Interleukin-17 gene polymorphisms are associated with bladder cancer in a Chinese Han population. Mol Carcinog. 2013;52(11):871-8. doi: 10.1002/mc.21928. [PubMed: 22692973].
  • 25. Lee YC, Chung JH, Kim SK, Rhee SY, Chon S, Oh SJ, et al. Association between interleukin 17/interleukin 17 receptor gene polymorphisms and papillary thyroid cancer in Korean population. Cytokine. 2015;71(2):283-8. doi: 10.1016/j.cyto.2014.11.011. [PubMed: 25484349].
  • 26. Nemati K, Golmoghaddam H, Hosseini SV, Ghaderi A, Doroudchi M. Interleukin-17FT7488 allele is associated with a decreased risk of colorectal cancer and tumor progression. Gene. 2015;561(1):88-94. doi: 10.1016/j.gene.2015.02.014. [PubMed: 25680555].
  • 27. Wang L, Jiang Y, Zhang Y, Wang Y, Huang S, Wang Z, et al. Association analysis of IL-17A and IL-17F polymorphisms in Chinese Han women with breast cancer. PLoS One. 2012;7(3). e34400. doi: 10.1371/journal.pone.0034400. [PubMed: 22461912]. [PubMed Central: PMC3312906].
  • 28. Isazadeh A, Hajazimian S, Tariverdi N, Rahmani SA, Esmaeili M, Karimkhanilouei S, et al. Effects of coagulation factor XIII (Val34Leu) polymorphism on recurrent pregnancy loss in Iranian Azeri women. J Lab Med. 2017;41(2):89-92. doi: 10.1515/labmed-2017-0012.
  • 29. Isazadeh A, Hajazimian S, Rahmani SA, Mohammadoo-Khorasani M, Samanmanesh S, Karimkhanilouei S. The effects of Factor II (rs1799963) polymorphism on recurrent pregnancy loss in Iranian Azeri women. Riv Ital Med Lab. 2017;13(1):37-40. doi: 10.1007/s13631-017-0145-y.

Featured Image:

Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments