Gene, Cell and Tissue

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Organic Cation Transporter 3 (Oct3), a Potential Suppressor for Hepatocellular Carcinoma

Bita Moudi 1 , 2 and Zahra Heidari 1 , 2 , *
Authors Information
1 Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
2 Department of Histology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
Article information
  • Gene, Cell and Tissue: 6 (1); e91387
  • Published Online: March 17, 2019
  • Article Type: Editorial
  • Received: March 9, 2019
  • Accepted: March 11, 2019
  • DOI: 10.5812/gct.91387

To Cite: Moudi B, Heidari Z. Organic Cation Transporter 3 (Oct3), a Potential Suppressor for Hepatocellular Carcinoma, Gene Cell Tissue. Online ahead of Print ; 6(1):e91387. doi: 10.5812/gct.91387.

Copyright © 2019, Gene, Cell and Tissue. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
Footnotes
References
  • 1. Moudi B, Heidari Z, Mahmoudzadeh-Sagheb H, Alavian SM, Lankarani KB, Farrokh P, et al. Concomitant use of heat-shock protein 70, glutamine synthetase and glypican-3 is useful in diagnosis of HBV-related hepatocellular carcinoma with higher specificity and sensitivity. Eur J Histochem. 2018;62(1):2859. doi: 10.4081/ejh.2018.2859. [PubMed: 29569872]. [PubMed Central: PMC5806503].
  • 2. Bachmakov I, Glaeser H, Endress B, Morl F, Konig J, Fromm MF. Interaction of beta-blockers with the renal uptake transporter OCT2. Diabetes Obes Metab. 2009;11(11):1080-3. doi: 10.1111/j.1463-1326.2009.01076.x. [PubMed: 19740083].
  • 3. Gasser PJ, Orchinik M, Raju I, Lowry CA. Distribution of organic cation transporter 3, a corticosterone-sensitive monoamine transporter, in the rat brain. J Comp Neurol. 2009;512(4):529-55. doi: 10.1002/cne.21921. [PubMed: 19025979].
  • 4. Heise M, Lautem A, Knapstein J, Schattenberg JM, Hoppe-Lotichius M, Foltys D, et al. Downregulation of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) in human hepatocellular carcinoma and their prognostic significance. BMC Cancer. 2012;12:109. doi: 10.1186/1471-2407-12-109. [PubMed: 22439694]. [PubMed Central: PMC3323414].
  • 5. Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N. Oct3/4 is potentially useful for the suppression of the proliferation and motility of hepatocellular carcinoma cells. Oncol Lett. 2018;16(4):5243-8. doi: 10.3892/ol.2018.9292. [PubMed: 30250594]. [PubMed Central: PMC6144932].
  • 6. Staal YC, van Herwijnen MH, van Schooten FJ, van Delft JH. Modulation of gene expression and DNA adduct formation in HepG2 cells by polycyclic aromatic hydrocarbons with different carcinogenic potencies. Carcinogenesis. 2006;27(3):646-55. doi: 10.1093/carcin/bgi255. [PubMed: 16269432].
  • 7. Vollmar J, Lautem A, Closs E, Schuppan D, Kim YO, Grimm D, et al. Loss of organic cation transporter 3 (Oct3) leads to enhanced proliferation and hepatocarcinogenesis. Oncotarget. 2017;8(70):115667-80. doi: 10.18632/oncotarget.23372. [PubMed: 29383190]. [PubMed Central: PMC5777802].

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