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Effect of rs4680 (Val158Met) Polymorphism of the COMT Gene on Opioid Addiction in an Iranian Population: A Case-Control Study

Fatemeh Dahmardeh ORCID 1 , * and Alireza Rezaeifar ORCID 2
Authors Information
1 Department of Biology, Faculty of Sciences, University of Zabol, Zabol, Iran
2 Department of Clinical Biochemistry, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran
Article information
  • Gene, Cell and Tissue: 6 (2); e91912
  • Published Online: May 18, 2019
  • Article Type: Research Article
  • Received: March 31, 2019
  • Revised: May 4, 2019
  • Accepted: May 12, 2019
  • DOI: 10.5812/gct.91912

To Cite: Dahmardeh F, Rezaeifar A. Effect of rs4680 (Val158Met) Polymorphism of the COMT Gene on Opioid Addiction in an Iranian Population: A Case-Control Study, Gene Cell Tissue. Online ahead of Print ; 6(2):e91912. doi: 10.5812/gct.91912.

Abstract
Copyright © 2019, Gene, Cell and Tissue. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
Footnotes
References
  • 1. Vasilev G, Milcheva S, Vassileva J. Opioid use in the twenty first century: Similarities and differences across national borders. Curr Treat Options Psychiatry. 2016;3(3):293-305. doi: 10.1007/s40501-016-0089-2. [PubMed: 27493878]. [PubMed Central: PMC4968876].
  • 2. Mohebbi E, Haghdoost AA, Noroozi A, Molavi Vardanjani H, Hajebi A, Nikbakht R, et al. Awareness and attitude towards opioid and stimulant use and lifetime prevalence of the drugs: A study in 5 large cities of Iran. Int J Health Policy Manag. 2018;8(4):222-32. doi: 10.15171/ijhpm.2018.128. [PubMed: 31050967]. [PubMed Central: PMC6499902].
  • 3. Kosten TR, George TP. The neurobiology of opioid dependence: Implications for treatment. Sci Pract Perspect. 2002;1(1):13-20. [PubMed: 18567959]. [PubMed Central: PMC2851054].
  • 4. Dasgupta N, Beletsky L, Ciccarone D. Opioid crisis: No easy fix to its social and economic determinants. Am J Public Health. 2018;108(2):182-6. doi: 10.2105/AJPH.2017.304187. [PubMed: 29267060]. [PubMed Central: PMC5846593].
  • 5. Agrawal A, Verweij KJ, Gillespie NA, Heath AC, Lessov-Schlaggar CN, Martin NG, et al. The genetics of addiction-a translational perspective. Transl Psychiatry. 2012;2. e140. doi: 10.1038/tp.2012.54. [PubMed: 22806211]. [PubMed Central: PMC3410620].
  • 6. Kreek MJ, Nielsen DA, Butelman ER, LaForge KS. Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction. Nat Neurosci. 2005;8(11):1450-7. doi: 10.1038/nn1583. [PubMed: 16251987].
  • 7. Kreek MJ, Bart G, Lilly C, LaForge KS, Nielsen DA. Pharmacogenetics and human molecular genetics of opiate and cocaine addictions and their treatments. Pharmacol Rev. 2005;57(1):1-26. doi: 10.1124/pr.57.1.1. [PubMed: 15734726].
  • 8. Diana M. The dopamine hypothesis of drug addiction and its potential therapeutic value. Front Psychiatry. 2011;2:64. doi: 10.3389/fpsyt.2011.00064. [PubMed: 22144966]. [PubMed Central: PMC3225760].
  • 9. Kaenmaki M, Tammimaki A, Garcia-Horsman JA, Myohanen T, Schendzielorz N, Karayiorgou M, et al. Importance of membrane-bound catechol-O-methyltransferase in L-DOPA metabolism: A pharmacokinetic study in two types of Comt gene modified mice. Br J Pharmacol. 2009;158(8):1884-94. doi: 10.1111/j.1476-5381.2009.00494.x. [PubMed: 19930170]. [PubMed Central: PMC2807650].
  • 10. Mannisto PT, Kaakkola S. Catechol-O-methyltransferase (COMT): Biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors. Pharmacol Rev. 1999;51(4):593-628. [PubMed: 10581325].
  • 11. Sun Z, Zhang Z, Mao P, Ma Y, Li W, Li J, et al. Association between COMT gene polymorphisms, clinical symptoms, and cognitive functions in Han Chinese patients with schizophrenia. Psychiatr Genet. 2018;28(3):47-54. doi: 10.1097/YPG.0000000000000194. [PubMed: 29634613].
  • 12. Voisey J, Swagell CD, Hughes IP, Lawford BR, Young RM, Morris CP. A novel SNP in COMT is associated with alcohol dependence but not opiate or nicotine dependence: A case control study. Behav Brain Funct. 2011;7:51. doi: 10.1186/1744-9081-7-51. [PubMed: 22208661]. [PubMed Central: PMC3268714].
  • 13. Omidvar M, Stolk L, Uitterlinden AG, Hofman A, Van Duijn CM, Tiemeier H. The effect of catechol-O-methyltransferase Met/Val functional polymorphism on smoking cessation: Retrospective and prospective analyses in a cohort study. Pharmacogenet Genomics. 2009;19(1):45-51. [PubMed: 19160592].
  • 14. Christoffersen DJ, Damkier P, Feddersen S, Moller S, Thomsen JL, Brasch-Andersen C, et al. The ABCB1, rs9282564, AG and TT genotypes and the COMT, rs4680, AA genotype are less frequent in deceased patients with opioid addiction than in living patients with opioid addiction. Basic Clin Pharmacol Toxicol. 2016;119(4):381-8. doi: 10.1111/bcpt.12602. [PubMed: 27061230].
  • 15. Demetrovics Z, Varga G, Szekely A, Vereczkei A, Csorba J, Balazs H, et al. Association between Novelty Seeking of opiate-dependent patients and the catechol-O-methyltransferase Val(158)Met polymorphism. Compr Psychiatry. 2010;51(5):510-5. doi: 10.1016/j.comppsych.2009.11.008. [PubMed: 20728009].
  • 16. Ahmed M, Ul Haq I, Faisal M, Waseem D, Taqi MM. Implication of OPRM1 A118G polymorphism in opioids addicts in Pakistan: In vitro and in silico analysis. J Mol Neurosci. 2018;65(4):472-9. doi: 10.1007/s12031-018-1123-1. [PubMed: 30033503]. [PubMed Central: PMC6132783].
  • 17. Hu R, Dai Y, Jia P, Zhao Z. ANCO-GeneDB: annotations and comprehensive analysis of candidate genes for alcohol, nicotine, cocaine and opioid dependence. Database (Oxford). 2018;2018. doi: 10.1093/database/bay121. [PubMed: 30403795]. [PubMed Central: PMC6310508].
  • 18. Gorwood P, Le Strat Y, Ramoz N, Dubertret C, Moalic JM, Simonneau M. Genetics of dopamine receptors and drug addiction. Hum Genet. 2012;131(6):803-22. doi: 10.1007/s00439-012-1145-7. [PubMed: 22350797].
  • 19. Levran O, Correa da Rosa J, Randesi M, Rotrosen J, Adelson M, Kreek MJ. A non-coding CRHR2 SNP rs255105, a cis-eQTL for a downstream lincRNA AC005154.6, is associated with heroin addiction. PLoS One. 2018;13(6). e0199951. doi: 10.1371/journal.pone.0199951. [PubMed: 29953524]. [PubMed Central: PMC6023117].
  • 20. Oueslati B, Moula O, Ghachem R. The impact of OPRM1's genetic polymorphisms on methadone maintenance treatment in opioid addicts: A systematic review. Pharmacogenomics. 2018;19(8):741-7. doi: 10.2217/pgs-2018-0017. [PubMed: 29785888].
  • 21. Mattay VS, Goldberg TE, Fera F, Hariri AR, Tessitore A, Egan MF, et al. Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine. Proc Natl Acad Sci U S A. 2003;100(10):6186-91. doi: 10.1073/pnas.0931309100. [PubMed: 12716966]. [PubMed Central: PMC156347].
  • 22. Lachman HM, Papolos DF, Saito T, Yu YM, Szumlanski CL, Weinshilboum RM. Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics. 1996;6(3):243-50. [PubMed: 8807664].
  • 23. Mukherjee N, Kidd KK, Pakstis AJ, Speed WC, Li H, Tarnok Z, et al. The complex global pattern of genetic variation and linkage disequilibrium at catechol-O-methyltransferase. Mol Psychiatry. 2010;15(2):216-25. doi: 10.1038/mp.2008.64. [PubMed: 18574484]. [PubMed Central: PMC2811226].
  • 24. Taylor S. Association between COMT Val158Met and psychiatric disorders: A comprehensive meta-analysis. Am J Med Genet B Neuropsychiatr Genet. 2018;177(2):199-210. doi: 10.1002/ajmg.b.32556. [PubMed: 28608575].
  • 25. Behbahani P, Kazemi-Nezhad SR, Foroughmand AM, Ahmadi L. Association study of single nucleotide polymorphism rs165599 of COMT gene, with schizophrenia and bipolar mood disorder in the south-west of Iran. Mol Biol Res Commun. 2015;4(2):67-72. [PubMed: 27843998]. [PubMed Central: PMC5019293].
  • 26. Saravani R, Galavi HR, Lotfian Sargazi M. Catechol-O-Methyltransferase (COMT) gene (Val158Met) and brain-derived neurotropic factor (BDNF) (Val66Met) genes polymorphism in schizophrenia: A case-control study. Iran J Psychiatry. 2017;12(4):265-70. [PubMed: 29472953]. [PubMed Central: PMC5816916].
  • 27. Horowitz R, Kotler M, Shufman E, Aharoni S, Kremer I, Cohen H, et al. Confirmation of an excess of the high enzyme activity COMTval allele in heroin addicts in a family-based haplotype relative risk study. Am J Med Genet. 2000;96(5):599-603. doi: 10.1002/1096-8628(20001009)96:5<599::aid-ajmg4>3.0.co;2-o.
  • 28. Lohoff FW, Weller AE, Bloch PJ, Nall AH, Ferraro TN, Kampman KM, et al. Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence. Neuropsychopharmacology. 2008;33(13):3078-84. doi: 10.1038/npp.2008.126. [PubMed: 18704099]. [PubMed Central: PMC2583214].
  • 29. Hosak L, Libiger J, Cizek J, Beranek M, Cermakova E. The COMT Val158Met polymorphism is associated with novelty seeking in Czech methamphetamine abusers: Preliminary results. Neuro Endocrinol Lett. 2006;27(6):799-802. [PubMed: 17187009].
  • 30. Beuten J, Payne TJ, Ma JZ, Li MD. Significant association of catechol-O-methyltransferase (COMT) haplotypes with nicotine dependence in male and female smokers of two ethnic populations. Neuropsychopharmacology. 2006;31(3):675-84. doi: 10.1038/sj.npp.1300997. [PubMed: 16395295].
  • 31. Guillot CR, Fanning JR, Liang T, Berman ME. COMT associations with disordered gambling and drinking measures. J Gambl Stud. 2015;31(2):513-24. doi: 10.1007/s10899-013-9434-1. [PubMed: 24390676]. [PubMed Central: PMC4082478].
  • 32. Cevoli S, Mochi M, Scapoli C, Marzocchi N, Pierangeli G, Pini LA, et al. A genetic association study of dopamine metabolism-related genes and chronic headache with drug abuse. Eur J Neurol. 2006;13(9):1009-13. doi: 10.1111/j.1468-1331.2006.01415.x. [PubMed: 16930369].
  • 33. Kweon YS, Lee HK, Lee CT, Pae CU. Association study of catechol-O-methyltransferase gene polymorphism in Korean male alcoholics. Psychiatr Genet. 2005;15(2):151-4. [PubMed: 15900232].
  • 34. Hallikainen T, Lachman H, Saito T, Volavka J, Kauhanen J, Salonen JT, et al. Lack of association between the functional variant of the catechol-o-methyltransferase (COMT) gene and early-onset alcoholism associated with severe antisocial behavior. Am J Med Genet. 2000;96(3):348-52. [PubMed: 10898913].
  • 35. Cao L, Li T, Liu X. [Association study of heroin dependence and catechol-O-methyltransferase gene]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2003;20(2):127-30. Chinese. [PubMed: 12673581].
  • 36. Oosterhuis BE, LaForge KS, Proudnikov D, Ho A, Nielsen DA, Gianotti R, et al. Catechol-O-methyltransferase (COMT) gene variants: Possible association of the Val158Met variant with opiate addiction in Hispanic women. Am J Med Genet B Neuropsychiatr Genet. 2008;147B(6):793-8. doi: 10.1002/ajmg.b.30716. [PubMed: 18270997]. [PubMed Central: PMC2909109].
  • 37. Enoch MA, Waheed JF, Harris CR, Albaugh B, Goldman D. Sex differences in the influence of COMT Val158Met on alcoholism and smoking in plains American Indians. Alcohol Clin Exp Res. 2006;30(3):399-406. doi: 10.1111/j.1530-0277.2006.00045.x. [PubMed: 16499480].

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