Research Article
30/4/2017
Tooba Nakhzari Khodakheir, Alireza Pourtalebi-Firoozabadi, Mohammad Hossein Sangtarash, Abbas Nikravesh
Myelin-directed autoimmunity seems to be an important factor in the pathogenesis of multiple sclerosis (MS). Growing productions of both anti-inflammatory and pro-inflammatory cytokines are frequent findings in MS. The IL-10 is an immunosuppressive cytokine in the immune system. In the clinical trial, it is considered to be ... read more
Research Article
29/4/2017
Fatemeh Safari, Sheyda Jodeiry Zaer
Helicobacter pylori CagA oncoprotein was injected into mammalian host cells via type IV secretion system, where it was tyrosine phosphorylated at the Glu-Pro-Ile-Tyr-Ala (EPIYA) sequence. Tyrosine phosphorylation of CagA was shown to be a prerequisite for the induction of actin cytoskeletal rearrangement in AGS gastric epithelial cells. ... read more
Research Article
30/4/2017
Jafar Vatandoost, Behnaz Dolatabadi
Selecting a host system for the expression of recombinant proteins should be carefully evaluated prior to the initiation of any bio therapeutic development programs. Since different hosts express proteins with various efficiencies and with different posttranslational modifications, changing hosts may impact the expected activity of the protein. ... read more
Research Article
30/4/2017
Marzie Bahadori, Fatemeh Amiri, Marjan Movahed, Amaneh Mohammadi Roushandeh, Mehryar Habibi Roudkenar
Hemolytic anemia is associated with intravascular heme release and oxidative stresses that lead to endothelial dysfunctions. Hemopexin (HPX) is a plasma heme-binding β1-glycoprotein, which plays a pivotal role in heme transfer to hepatocytes and iron recycling. Recently, HPX administration in hemolytic patients attenuated hemolysis-driven oxidative damages and ... read more
Research Article
30/4/2017
Atefeh Tahervand, Behnaz Parnian, Mehryar Habibi Roudkenar, Amaneh Mohammadi Roushandeh
Digoxin, which is used in heart failure patients, contributes to inhibition of cell proliferation and induction of apoptosis. Therefore, digoxin could have a therapeutic potential in helping determine which individuals may suffer from cancer. This study was conducted to determine whether digoxin declines HeLa cells proliferation and ... read more
Research Article
30/4/2017
Mehrnaz Narooie-Nejad, Somayeh Nezam-Abadi, Morad-Ali Ranaei, Mahdie Bagherzade-Yazdi, Mojgan Mokhtari
Recurrent miscarriage (RM) is defined as the presence of two or more spontaneous abortions. It has been estimated that 1% to 3% of couples experience RM. Furthermore, RM is considered as a multifactorial disease and genetic disorders are one of the suggested issues. In this study, 30 ... read more
Letter
30/4/2017
Ramin Saravani, Hamid Reza Galavi
Letter
14/11/2016
Sayed Alireza Mirsane, Shima Shafagh, Nasrin Oraei
Letter
30/4/2017
Maryam Moossavi, Mostafa Ibrahimi, Milad Mohammadoo-Khorasani
Letter
30/4/2017
Sayed Alireza Mirsane, Shima Shafagh, Nasrin Oraei

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